Sentence examples for mediated toxicity in from inspiring English sources

Treatment with methylene blue, an aggregation inhibitor of the phenothiazine class, not only rescued toxic phenotypes (including neuronal dysfunction and oxidative stress) associated with mutant TDP-43 and FUS in C. elegans and zebrafish ALS models [62], but also ameliorated Tau mediated toxicity in a newly established C. elegans model [36].

Together, these results thus reveal a requirement of TDP-43 RNA-binding activity for TDP-43 mediated toxicity in vivo.

Therefore, both overexpression of Grx1 or pretreatment of cells with estrogen, which in turn upregulates Grx1, provide protection against L-BOAA mediated toxicity in SH-SY5Y cells (Fig. 8E).

However, NAC also reduces ONOO− mediated toxicity in various pathophysiological conditions [ 69, 154, 155].

Furthermore other studies have shown that after translocation from the primary site of exposure, the NMs can induce oxidative stress - mediated toxicity in many cell types by producing large amounts of free radicals [ 12, 35, 36].

Therefore, HDAC inhibitors which promote histone acetylation over deacetylation and which were also known to provide protection against polyQ mediated toxicity in vertebrate and Drosophila neurons may hold promise as a preventive therapy in polyQ diseases.

Additionally, P4D6 inhibited Aβ amyloid-mediated toxicity in cultured neuronal cells.

Although overexpression of XPO7 alone increased the cumulative risk of death by nearly 100%, it had little effect on TDP43-mediated toxicity in primary neurons (Fig. 8g).

ApiCCT1(r) reduces mHtt-mediated toxicity in immortalized striatal cells derived from full-length knock-in HD mice, suggesting that therapeutic benefit may extend beyond effects on aggregation.

The present study has been designed and carried out to explore the role of grape seed proanthocyanidins (GSP) in the pancreas of cadmium (Cd -induced Cd -inducedidative stress-mediated toxicellularrats.

Finally, as a first step in the study of this cellular model, we observed a 42 48% reduction of menadione/BNAH-mediated toxicity in QR2 shRNA cells compared to the wild-type HT22 cells.