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We subsequently describe how access is mediated to this data space and illustrate the capabilities of the system using examples supporting on-going studies of T. gondii virulence.
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To examine the ability of LGP2 to mediate responses to this intracellular pathogen, wild-type and LGP2-deficient MEFs were infected with LM and cellular responses monitored.
This possibility can be extended to bacterial, protozoan, helminth, and fungal coinfections, given the discovery that TLR2 is involved in mediating resistance to this parasite [ 53].
Based on this analysis, WRKY33 appears to have a prominent repressive role on the transcription of many specific host genes indicating a negative regulatory function of WRKY33 in mediating immunity to this pathogen.
The intriguing implication of these studies is that retinal circuitry and higher order neuronal processes are either sufficient or adapt to mediate this augmentation to congenital vision.
But whether FTIs can alleviate the disease phenotype in Drf1-null or heterozygous mice and whether RhoB is required in vivo to mediate this response remains to be determined.
If anyone doubts his ability to mediate, consider this: he put it to the test when he told his parents he was headed for the monastery instead of the bar exam.
It was suggested that immunological tolerance and steroid mediated growth led to this exacerbation during pregnancy.
Furthermore, stress responses appear to be mediated by this system in controlling life span in worms.
These studies have clearly implicated both the type II topoisomerases and the mitochondria as targets that mediate hypersensitivity to this cytotoxic drug.
In this study, we used FCR3Δvar2csa mutant parasites to investigate if var2csa is essential for HA cytoadhesion and if the parasite genome encodes for other parasite ligands that mediate binding to this receptor.
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