Sentence examples for mediated tissue destruction from inspiring English sources

TUNEL staining in these mice appears confluent, especially around blood vessels and highlighting large foci of necrotic infiltrates that have been shown to be rich sources of damage associated molecular patterns (DAMPs) that can potentially further exacerbate host mediated tissue destruction [14], [17].

Serine protease inhibitors such as SLPI act locally to maintain a protease/antiprotease balance thereby preventing protease mediated tissue destruction [ 7].

These data argue that TCR-redirected Tregs are indeed capable of suppressing Teff cell responses in vivo, and further demonstrate that antigen-specific Tregs are more potent than polyclonal Tregs in limiting Teff-cell mediated tissue destruction.

Our results clearly support an immunopathological role for neutrophils by mediating tissue destruction, which resulted in significant early mortality.

The SLPI has previously been reported to be upregulated in arthritic joints and to mediate tissue destruction and inflammation in a rat model of arthritis induced by intraperitoneal injection of SCW [ 26].

Neutrophils are also believed to be the more important for the development of chronic obstructive pulmonary disease (COPD), because of their ability to release elastase which mediates tissue destruction [ 46].

As well as mediating tissue destruction, RASFs play a major role in catalyzing and sustaining RA by producing inflammatory cytokines such as interleukin-1-beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), proangiogenic factors, and matrix-degrading enzymes [ 1, 2].

RA-FLSs not only mediate tissue destruction but also are considered to play a major role in initiating and driving RA in concert with inflammatory cells [ 7].

Interestingly, a polymorphism in the 3'-UTR of the miR-146a target gene was recently shown to be associated with RA susceptibility [ 86]. miR-155 overexpression in synovial fibroblasts was able to prevent the TLR and cytokine-inducible expression of specific matrix metalloproteinases that mediate tissue destruction in RA [ 81].

The switch not only can lead to tumor rejection but more in general to all forms of immune-mediated tissue destruction processes including flares of autoimmunity, clearance of pathogen-infected cells, allograft rejection and graft versus host disease.

Furthermore, tissue macrophages co-infected with opportunistic pathogens such as Mycobacterium Avian Complex (MAC) or Pneumocystis carinii dramatically increase viral production and the likelihood of macrophage-mediated tissue destruction [43].