Sentence examples for mediated through reductions from inspiring English sources

These benefits, however, do not seem to be mediated through reductions in the overall duration of injecting and might be associated with prolonged duration, albeit at reduced frequency during treatment.

Indeed, antagonism of vasopressin receptors has been advocated as therapy for congestive heart failure; both animal models of congestive heart failure and early clinical studies support the notion that antagonism of V1Rs and V2Rs leads to an improvement in cardiac function, probably mediated through reductions in cardiac afterload [ 76- 78].

In both treatment methods, these beneficial effects might be mediated through reduction of anaphylatoxic C5a activity and subsequent inhibition of inflammation and apoptosis pathways.

We attribute this effect to the anti-inflammatory effect of Ral that could be mediated through reduction of IL-1β, TNF-α and IL-8, all can be released by inflamed colonic cells [26].

This inhibition may be mediated through reduction in the levels of growth factors [ 34], analogous to the reduction of insulin or IGF-1, as was shown here.

Such protective effects are possibly mediated through reduction of calcium overload, the mitochondrial intrinsic apoptotic pathway, and the MAPK signaling pathway.

It has been proposed that DR lifespan extension is mediated through reduction of mTORC1 signaling, and activation of sirtuins and other NAD+-dependent mechanisms through an increase in respiration (Guarente, 2013; Johnson et al., 2013).

As with T-cells, this blockage appeared to be partly mediated through reduction in the expression of the miR-17 92 miR-17 92hiclusterlts in the increased expression of its targets, the pro-apoptotic protein Bim and the tumour suppressor, PTEN [ 21,33,34].

Our results demonstrate that the orally administered fractions of latex of C. procera are effective in attenuating yeast-induced pyrexia and this effect is mediated through reduction in the levels of PGE2.

37 38 Of note, a study in mice has indicated that low carbohydrate-high protein diets may have substantial adverse vascular effects not reflected in serum markers but mediated through reduction of bone marrow and peripheral blood endothelial progenitor cells, 11 which are considered a marker of vascular regenerative capacity.

The primary effect of losartan on tissue remodeling in Marfan syndrome is likely to be mechanosensitive, mediated through reduction in blood pressure, since treatment with β1 receptor antagonists slows aortic dilatation to a similar degree as losartan (Lacro et al, 2014).