Sentence examples for mediated through reduction from inspiring English sources

The anti-inflammatory effects of EPA are mediated through reduction of arachidonic acid- derived inflammatory mediators, activation of nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) and G protein coupled receptor (GPR) 12020 as an agonist, and stimulation of the AMPK/SIRT pathway21.

In our cohort, the effects of n-3 PUFA on insulin sensitivity may be mediated through reduction of free fatty acids.

In both treatment methods, these beneficial effects might be mediated through reduction of anaphylatoxic C5a activity and subsequent inhibition of inflammation and apoptosis pathways.

We attribute this effect to the anti-inflammatory effect of Ral that could be mediated through reduction of IL-1β, TNF-α and IL-8, all can be released by inflamed colonic cells [26].

Such protective effects are possibly mediated through reduction of calcium overload, the mitochondrial intrinsic apoptotic pathway, and the MAPK signaling pathway.

This inhibition may be mediated through reduction in the levels of growth factors [ 34], analogous to the reduction of insulin or IGF-1, as was shown here.

These benefits, however, do not seem to be mediated through reductions in the overall duration of injecting and might be associated with prolonged duration, albeit at reduced frequency during treatment.

Indeed, antagonism of vasopressin receptors has been advocated as therapy for congestive heart failure; both animal models of congestive heart failure and early clinical studies support the notion that antagonism of V1Rs and V2Rs leads to an improvement in cardiac function, probably mediated through reductions in cardiac afterload [ 76- 78].

Overall, the present results indicate that Ost suppresses the RV remodeling process induced by MCT in rats, which may be at least partially mediated through the reduction of myocardial apoptosis and inflammation.

Improvement in functioning among patients on lurasidone was largely mediated through a reduction in depression symptoms, but lurasidone also had a medium and statistically significant independent direct effect in improving functioning.

It has been suggested that this effect is mediated through a reduction in satiety [27] and consequent increased food consumption [28].