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We found that the pro-angiogenic effects are partly mediated through reduced repression by miR-101 of the histone-methyltransferase EZH2, a member of the Polycomb group family, thereby increasing methylation of histone H3 at lysine 27 and transcriptome alterations.
While there was some indication that the physiological cost of rapid growth in terms of reduced cold resistance was mediated through reduced Hsp70 levels there was no support for this at the individual level.
The findings suggest that the effect of maternal smoking on neonatal mortality is largely mediated through reduced fetal growth.
We performed analyses in order to investigate whether the effect of prednisolone was mediated through reduced inflammation.
20 A recent clinical trial indicated reduced OA knee pain after treatment with strontium ranelate, an effect that may be mediated through reduced bone turnover.
For example, a causal relationship may exist between SEB and stage, perhaps mediated through reduced health awareness and later presentation amongst those in more deprived areas.
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Our results demonstrate prednisolone can has an anti-inflammatory effect mediated through reducing serum circulating cytokines.
Our findings suggest that the beneficial effect of physical activity on breast cancer risk could be mediated through reducing mammographic density.
12 As macrolides have been demonstrated to reduce MMP activity in lung diseases, including COPD, 11 13 14 we hypothesised that beneficial effects of azithromycin might be mediated through reducing PGP.
Additionally, Levin et al. (2005) showed that exposure of healthy human leukocytes to the NDL-PCBs 138, 153, and 180 resulted in reduced phagocytosis mediated through both reduced neutrophil and monocyte activity, the effects of which were more pronounced with exposure to mixtures of multiple NDL-PCBs.
The question then arises: "What factors counterbalance the beneficial effects of reduced resident fatigue?" One commonly articulated factor is lack of continuity, mediated through both reduced direct contact with patients and increased frequency of handovers [ 41- 44].
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CEO of Professional Science Editing for Scientists @ prosciediting.com