Questions as to whether aspirin-induced apoptosis is mediated through Cox inhibition are raised by observations that NSAIDs that inhibit neither Cox-1 or Cox-2 induce apoptosis and, that low-dose salicylates inhibit apoptosis in vitro possibly by direct effects on apoptosis-regulating genes such as Bcl2 and Bax (Elwood et al, 2009).
Assuming that this surprising clinical response is based on inhibiting estrogen-stimulated growth mediated through functional ER, it raises several questions regarding the nature of stem or progenitor cells that could produce and sustain such heterogeneous populations in the first place, yet still respond in a similar manner to hormonal therapy.
This cytotoxicity was mediated through HLA proteins that are highly prevalent, raising the possibility that vaccines or immunotherapies that might induce cytotoxic function could do so in a large portion of the population.
A subset of proteins co-immunoprecipitating with PepD in both M. tuberculosis and M. smegmatis are predicted to localize to the cytoplasmic compartment, raising the possibility that additional interactions may be mediated through this domain.
CONCLUSIONS: These data raise the possibility that the clinical benefit of pexelizumab is mediated through novel pathways such as reduction in apoptosis or other mechanisms.
The threshold of the cold-responsive C-fibre afferents was raised in inflammation, indicating the development of a cold allodynia mediated through changes in primary afferent properties, consistent with reported behavioural changes (Obata et al., 2005).
However, niacin treatment has also been shown to increase plasma levels of the adipocyte-derived atheroprotective hormone, adiponectin [16] raising the possibility that some of the effects of NA may be mediated through lipid-independent pathways.
Hypothyroidism resulted in a significant decrease in Smo mRNA levels selectively in the DG, raising the intriguing possibility that the neurogenic decline observed in hypothyroid animals may be mediated through a reduced responsivity to Shh signaling.
These results raise the possibility that the antineoplastic properties of 15-PGJ2 ate, at least partially, mediated through PPARγ-independent mechanisms.
These findings raise the immediate question of whether reported BPA-related endocrine disruption might actually be mediated through ERR-γ rather than through ER.
