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The results exhibited significant toxicity of Ni NPs in human lung epithelial A549 cells which is likely to be mediated through oxidative stress.
Inflammatory effects of NPs were dependent on the surface area and were mediated through oxidative stress as they were inhibited by catalase.
However, whether BK induced MMP-9 expression mediated through oxidative stress remains virtually unknown.
Our results revealed that MeHg induced toxicity is predominantly mediated through oxidative stress mechanism and the propensity of Tagara to abolish such reactions.
Multiple mechanisms that link iron with abnormal glucose metabolism have been proposed, including β-cell dysfunction and insulin resistance, possibly mediated through oxidative stress (1).
These studies suggest that upregulation and activation of MMP-9 by proinflammatory factors are mediated through oxidative stress (ROS production) during brain injury and inflammation.
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Periodontitis has been causally linked to cardiovascular disease, which is mediated through the oxidative stress induced by periodontitis.
Direct effects on the cardiovascular system, blood, and lung receptors, as well as indirect effects mediated through pulmonary oxidative stress and inflammatory responses, have been observed.
Brook et al. (2004) suggested possible biological mechanisms linking PM exposures with cardiovascular disease (e.g., direct effects of pollutants on the cardiovascular system, blood, and lung receptors, indirect effects mediated through pulmonary oxidative stress and inflammatory responses).
Acute hyperglycaemia is an independent cardiovascular risk factor in Type 2 diabetes which may be mediated through increased oxidative damage to plasma low density lipoprotein, and in vitro, high glucose concentrations promote proatherogenic adhesion molecule expression and matrix metalloproteinase expression.
Several hypotheses have been proposed, including direct effects of pollutants on the cardiovascular system, blood, and lung receptors, and/or indirect effects mediated through pulmonary oxidative stress and inflammatory responses (Brook et al. 2004), potentially also leading to structural changes with lasting damage of the cardiovascular system.
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