Sentence examples for mediated through multiple from inspiring English sources
But, the scientists wrote, "the original hypothesis was overly simplistic because the effects of diet on coronary heart disease can be mediated through multiple biological pathways other than serum total cholesterol or low-density lipoprotein cholesterol".
The overall effect of woody vegetation on crop yields is mediated through multiple processes and shows both positive and negative effects.
We also examined the domains of Sox2 necessary to mediate its self-association, and we determined that Sox2 self-association is mediated through multiple domains.
These effects are mediated through multiple signaling pathways, including the Ras, ERK [8], the JAK/STAT [9] and the PI3K-1A and -1B pathways [10], [11].
BM-derived cells can differentiate into various cell types in the tumor microenvironment and the anti-tumor effect of Hh blockade may be mediated through multiple players in the cancer stroma [33].
Our observations are in accordance with previous studies demonstrating that the neurotoxicity elicited by soluble Aβ upon neurons involves elevated K+ efflux, mediated through multiple pathways including enhanced activity of voltage-gated potassium channels [22], [23] and the Na+/K+ ATPase [24], [25].
For the second question, that of the direct effect of temperature on mortality not mediated through ozone, multiple approaches for estimation exist (Petersen et al. 2006; VanderWeele 2009).
Such connexin functions are mediated through their multiple interacting partners, independent of channel formation, and subsequently lead to the modulation of gene expression resulting in a wide range of effects [ 135].
Signalling through the PDGF receptor is mediated through interactions with multiple SH2 domains including phospholipase-C (PLC) γ1, phosphatidylinositol 3-kinase (PI3K) and Ras/Raf-1 [ 9].
At least some effects of EFNL treatment are mediated through deregulation of multiple pathways (apoptosis, angiogenesis, cell cycle, and signaling) that are critical for mammary tumor promotion and progression.
ROS scavenging also reversed the effects of DE inhalation, supporting a role for increased oxidative stress, which can decrease NOS mediated dilation through multiple pathways.
