Sentence examples for mediated through mitochondrial from inspiring English sources
We have shown that apoptotic cell death mediated through mitochondrial and caspase pathways plays a critical role in disease progression in HSPB5 R120G cardiomyopathy [18].
Researchers identified the mechanism as mediated through mitochondrial toxicity and autophagy activation.
The primary pathological manifestation of kidney injury in MMA may be mediated through mitochondrial dysfunction in the proximal renal tubule, as has been described in a Mut mouse model.
The study suggests that, PAC-1-induced mitochondrial permeabilization is mediated through mitochondrial calcium overload and mitochondrial reactive oxygen species (ROS), assisted by endoplasmic reticulum (ER) oxidoreductin-1 alpha (Ero1 α -dependent calcium release from the ER.
It has been hypothesized that JNK-dependent apoptosis is mediated through mitochondrial cytochrome c release, which has also been observed as an early event in UV-mediated apoptosis in HaCaT cells.
In order to determine whether LCA-induced apoptosis is mediated through mitochondrial dysfunction, the mitochondrial membrane potential (MMP) is measured by using the mitochondrion-sensitive dye JC-1, as shown in Figure 4(a), the cells were stained with JC-1, and the percentages of cells with green-positive and red-negative fluorescence were scored as depolarized cells.
Further studies showed that the increase in ROS levels in response to HKII knockdown or mitochondrial dissociation is mediated through increased mitochondrial permeability and not by a significant change in antioxidant defenses.
The link between Myc deficiency and apoptosis is less clear, but may also be mediated through a mitochondrial pathway [ 42].
This observation shows that rhSIRT1 has an antiapoptotic effect mediated through the mitochondrial pathway under LN conditions.
This indicates that CycD/Cdk4's pathological consequences are mediated through altered mitochondrial function and a concomitant increase in reactive oxygen species.
We also found that apoptosis of both AF and NP cells is mediated through the mitochondrial pathway in a rat tail static compression model of disc degeneration [ 28].
