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Several studies have also suggested that part of the effect of statins on CVD is mediated through lowering of CRP concentrations [ 6– 10].
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Further studies are required to confirm our results and to figure out if the protective effect is mediated through lowered cholesterol level or better antioxidant properties.
Results indicated that sexual orientation-related discrimination experiences were significantly and positively associated with anxiety and that this association was mediated through lower distress tolerance.
Some of the association was mediated through lower physical fitness among those with lower stress resilience.
If there is an impact it may be mediated through lower health literacy and less education; therefore, we included education status and health literacy in our analyses.
The beneficial effects of physical activity on CVD risk are mediated through a lowering of blood pressure, increasing HDL cholesterol, reducing body fat and reducing insulin resistance[ 7].
For instance, native peptide sequences of PGC-1α and FOXO3a supported activation by STACs which was dose-dependent and mediated through a lowering of peptide Km.
In many animal species, STZ induces diabetes that resembles human hyperglycemic nonketotic diabetes mellitus and this effect has been extensively studied and appears to be mediated through a lowering of beta cell nicotinamide adenine dinucleotide (NAD+) and results in histopathologic alteration of pancreatic islet beta cells [ 16, 17].
Our path analysis shows that there is an indirect effect of magnesium on MS, mediated through T2DM; lowering magnesium levels will increase the odds of T2DM which again increases the odds of MS. Bayesian methods has only been used to a limited extent in clinical research, but the WinBUGS software has made Bayesian methods more easily available [ 45].
This suggests that the associations are mediated through the lowered BP per se and not the specific mechanism of action of the antihypertensive medications.
Since, the effects of distal variables are mediated through proximate variables; lower level variables cannot be a confounder for upper level variables.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com