Sentence examples for mediated through epigenetic from inspiring English sources

These effects may be mediated through epigenetic or genetic mechanisms.

Further, there is evidence for active selection against expression in metastatic lesions, mediated through epigenetic gene silencing.

> Many cancers involve multiple factors like environmental factors or genetic factors with impact on interlinked biological pathways and the environmental effects are mediated through epigenetic modifications.

Although the exact functional significance of these SNPs has not been clarified, biological studies have suggested that the effect of the risk alleles can influence the methylation capability and at least in part be mediated through epigenetic alterations [ 26, 27].

In addition, in this report, we show that unstable resistance to low levels of amp in E. coli can be mediated through epigenetic events, likely stochastic in nature, yet semi-stable, that result in elevated AmpC expression.

Since unknown mechanisms are believed to repress a large number of the OLFR genes all the time in most of the cell types, it is likely that these repression mechanisms are mediated through epigenetic modifications.

Current understanding of environmental cross-talk with genetic makeup is found to be mediated through an epigenetic interface which is associated with prominent reversible and heritable changes at gene expression level.

It has been proposed that the protective effect of folic acid may be mediated through an epigenetic mechanism, involving enhanced DNA and/or histone methylation.

Based on the developmental origins of the health and disease hypothesis or fetal programming (4), the intrauterine environment represents a time when changes in maternal metabolism may affect distant metabolic dysfunction in the offspring mediated through physiological and/or epigenetic mechanisms.

Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through epigenetic priming of cancer-initiating cells, suggesting that genetic lesions that initiate the cancer process might be dispensable for the posterior tumor progression and maintenance.

We also provide data suggesting that the inactivation of these receptors is mediated through both genetic and epigenetic mechanisms.