Sentence examples for mediated through elevated from inspiring English sources

We suggest this negative relationship is mediated through elevated diacylglycerol production and chronic down-modulation of protein kinase C. Protein kinase C is known to be essential for expression of differentiation-related genes in keratinocytes.

There is also growing evidence that low socioeconomic position in early life, as well as in adulthood, is associated with CHD risk [23]; which could be mediated through elevated circulating inflammatory markers [6,24].

However, experimental color enhancement of the plumage has clearly demonstrated a positive effect on male fertilization success in a New York population (Safran et al. 2005), presumably mediated through elevated androgen levels (Safran et al. 2008).

The recognition of human rhinovirus, human parechovirus 1, rotavirus or coxsackie B virus by different host cells are mediated through elevated TLR2, 7, 8 and (or) Mda5 expression, which induce secretion of proinflammatory cytokines, chemokines, and interferons [ 16- 19].

High body mass index (BMI) has been implicated in the development of asthma in industrialized countries [ 14] however, the relationship between high BMI and atopy is not clearly established [ 15], but potentially mediated through elevated production of leptin, tumor necrosis factor α (TNFα) and interleukin-6 associated with increased adiposity.

Our observations are in accordance with previous studies demonstrating that the neurotoxicity elicited by soluble Aβ upon neurons involves elevated K+ efflux, mediated through multiple pathways including enhanced activity of voltage-gated potassium channels [22], [23] and the Na+/K+ ATPase [24], [25].

Stimulation of TLR5 by flagellin is mediated through the signaling mediators MAPK p38 and ERK, which also were elevated in the monocytes of older compared with younger donors.

As2O3 treatment dramatically elevated SnoN levels likely mediated through a ROS-dependent pathway.

These improvements were observed after 2 weeks to 6 months of treatment and are believed to be mediated through blockade of the effects of angiotensin II, the levels of which are elevated during exercise.

Our results thus far demonstrated that in non-GC-DLBCL, elevated levels of miR-155, and consequent abrogation of SHIP1 expression, are mediated through autocrine stimulation of cells by TNFα, a proinflammatory cytokine whose serum levels are known to be elevated in DLBCL patients (Pedersen et al, 2005).

This response is likely to be mediated through LPA4, which, in contrast to the EDG family receptors, elevates cAMP and is highly expressed in the ovary (Noguchi et al., 2003).