Sentence examples for mediated through downregulation from inspiring English sources

These data suggest the activation of caspase-8 is probably mediated through downregulation of c-FLIP and that activated caspase-8 plays a partial, but pivotal, role in the apoptosis induction by these compounds.

To establish that the effect of miR-125b on the distribution of actin filaments was mediated through downregulation of TEF, we flow sorted DsRed-positive wild type fibroblasts cotransfected with a TEF cDNA lacking the mir-125b binding site, which were subsequently transfected with miR-125b.

Although preliminary, some evidence from this study suggests that induction of differentiation upon clorgyline treatment might be mediated through downregulation of EZH2.

As we could not demonstrate direct regulation of KIT by miR-17/20a miR-17/20aer the observed reduction of KIT protein in GIST cells transfected weth miR-17/20a to be an indireconsiderdary effecthepobservedmediated threductionnregulatiof of additional target genes.

As NF- κB has been recognized as an important molecular link between inflammation and cancer, it is possible that the anti-inflammatory and chemopreventive effects of Nrf2 inducers or Nrf2-regulated gene products may be mediated through downregulation of NF- κB.

Since EG3287 had no significant effect on the cell expression of integrin- β1 (data not shown), the inhibitory effects of the NRP1 antagonist on carcinoma cell responses, including adhesion and migration, were unlikely to have been mediated through downregulation of integrin- β1 expression.

Collectively, these results indicate that the anti-tumor effect of cyclopamine on xenograft growth is primarily mediated through a downregulation of Hh signaling in tumor-associated stroma.

This inhibition may be mediated through a downregulation of Akt phosphorylation.

Given that Ctgf promotes DNA synthesis in chondrocytes, osteoblasts and fibroblasts [ 26], the observed decrease in proliferation could be mediated through Ctgf downregulation.

By demonstrating that TLN functionally interacts with ARF6 via EFA6A, we now show that the function of ARF6 in positively regulating spine maturation is at least in part mediated through the downregulation of TLN surface expression in dendritic filopodia.

This is mediated through the downregulation of cell cycle regulatory genes, such as CDC25B, PLK1, Aurora B kinase, Cyclin B1, PLK1, MYC, BUB1B and CENPF, which are under transcriptional control of FOXM1 [2].