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Mechanistically, AAMs recruited during chronic T. crassiceps infection are able to suppress immunological events mediated through distinct molecular pathways that may induce strong proinflammatory responses.
These data suggest that the differential roles for FOXOs in promoting polarity and axon outgrowth are mediated through distinct downstream effectors.
However, knocking down TOR extends lifespan further in ife-2 deleted worms, indicating that the effects of TOR and ife-2 are mediated through distinct mechanisms [ 42], further discussed in section 4.2.
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That stew of references is still visible in Ms. Snyder's new paintings, only now mediated through two distinct filters: Claude Monet and Joan Mitchell.
The pleiotropic actions of TNF-α are mediated through two distinct cell surface receptors: 55 kDa TNFR1 (p55, or CD120a) and 75 kDa TNFR2 (also called p75, and CD120b) (reviewed in [4]).
The pleiotropic effects of TNF-α are mediated through two distinct TNF receptors, the type 1 p60/p55 receptor (TNFR1) and the type 2 p80/p75 receptor (TNFR2) [ 3, 4].
These effects are mediated through two distinct G-protein-coupled receptors; the BK (bradykinin) B1R (B1-receptor) and B2R (B2-receptor).
The biological activity of TNF is mediated through two distinct but structurally homologous TNF receptors, type I (p60 or p55) and type II (p80 or p75).
The actions of RA are mediated through six distinct ligand-dependent transcription factors, including three RA receptors (RARα, β and γ) and three retinoid X receptors (Zhou et al., 2008).
Based on the cardioprotective effects of glucagon-like peptide-1 (GLP-1) [ 30] or its analogs (such as exenatide) [ 61, 103], administered at the onset of reperfusion, their combination with RIC resulted in a significant reduction of infarct size as compared to the individual treatments alone and appeared to be mediated through two distinct pro-survival pathways [ 4].
Hence, our results demonstrated that segregation of different sensory signals, such as olfactory and thermosensory signals, is mediated through not only distinct signal transductions in a sensory neuron but also discrete neurotransmissions in downstream neural circuits.
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