Sentence examples for mediated through direct from inspiring English sources

The effect of PDT is mediated through direct ablation and immune-mediated vascular stasis [ 11, 16].

The findings from this study show that the non-transformed cell types and the ECM of the bone marrow are modified early in the development of leukemia, most likely via interactions that are mediated through direct cell contact and secreted cytokines, chemokines and other factors.

We also found that neither MC3-R protein nor mRNA was expressed in mouse kidney, suggesting that renal Gamma-MSH action may not be mediated through direct effects on tubular Na transport but rather through effects on central neural pathways that innervate the kidney.

Intercellular communication plays an essential role in multicellular organisms and can be mediated through direct cell cell contact or through the transfer of secretory molecules.

On the other hand, this capacity does not imply that the biological properties of H2S are exclusively mediated through direct effects on the mitochondria [170].

It also remains unclear whether this beneficial effect is mediated through direct effects of incretin hormones on contractile function or changes in myocardial glucose delivery [8].

The exact role which the vitamin B-6 compounds play as antioxidants is not clear yet; however, they might mediate through direct or indirect mechanism.

Although the scope of this study may not permit elucidation of the specific mechanisms associated with the actions of MESC on humoral and cell-mediated immunity, augmentation or modulation of the immune system is supposedly mediated through opsonization, direct neutralization of antigen, agglutination of antigen and activation of complement system to cause lyses and death of antigenic cells [ 37].

The localization of the CRB3 Pals1–PATJ complex at the TJ is mediated through a direct and PDZ domain-dependent interaction of Pals1 with the C-terminal PDZ domain motif in CRB3, and a direct interaction between Pals1 and PATJ involving the L27N domain of Pals1 and the L27 domain present at the NH2-terminal region of PATJ (Fig.  3) (Roh et al. 2002b).

Our work further reveals that ActivinB expression is mediated through a direct modulation of H3K27me3 marks on the Inhbb locus in Menin-KO cell lines.

The observed alterations of the species composition of the autotrophic communities as well as of the rotifers were most likely caused indirectly by cypermethrin, mediated through the direct negative effects of the insecticide on the crustacean grazers.