Sentence examples for mediated through decreased from inspiring English sources

The present studies suggest that the diabetogenic impact of the C-allele of rs4607103 near ADAMTS9 may in part be mediated through decreased insulin sensitivity of peripheral tissues.

ChIP analysis and luciferase assays reveal that the downregulation of key repair genes is mediated through decreased recruitment of the E2F1 transcription factor and not through active repression by repressive E2Fs.

To determine whether the effects of Hr are mediated through decreased expression and activity of p53, the effects of Hr on apoptosis were examined in mouse embryonic fibroblast (MEF) cell lines derived from p53 knock out and wild-type mice.

Associations with increased blood pressure are believed to be mediated through decreased renin production [36] and it has been suggested that (independently of blood pressure), this could also affect vascular stiffness [33].

In conclusion, the present studies of non-diabetic Europeans suggest that the diabetogenic impact of the C-allele of rs4607103 near ADAMTS9 may in part be mediated through decreased insulin sensitivity of peripheral tissues.

Functional analysis indicated decreased hypocretin messenger RNA and peptide content, and increased sleep in transgenic mice overexpressing human IGFBP3, an effect possibly mediated through decreased hypocretin promotor activity in the presence of excessive IGFBP3.

Moreover, the inhibitory effect of BMP-6 on miR-21-induced invasion was also mediated through decreasing δEF1 and c-Fos/c-Jun expression.

Growth hormone affects cellular growth through the actions of insulin growth factors, and it has been suggested that the beneficial effect of caloric restriction on CRC risk is mediated through decreasing IGF-1 [47].

Because any effect of metformin may be mediated through decreasing severity of organ dysfunction, we assessed acute organ dysfunction on the day of ICU admission using the laboratory cutoff values in the Sequential Organ Failure Assessment (SOFA) score criteria for kidney, liver, and coagulation system dysfunction [ 31].

As claudin-7 is involved in the regulation of the epithelial permeability, we found it plausible that the increased epithelial leakiness observed during carcinogenesis could be mediated through a decreased level of claudin-7.

In DU145 cells, cells are less sensitive to SMA-Ral treatment and the mechanisms may be mediated through a decreased expression of the EGFR at the membrane and subsequent downstream effectors.