Sentence examples for mediated through classical from inspiring English sources

To determine whether the effects of FGF8b on Gnrh expression in GT1-7 cells were mediated through classical FGF receptors, cells were treated with the broad FGF receptor antagonist PD173074.

Whether the association is mediated through classical risk factors or independent of these is not clearly established.

The small molecule Bcl-2 inhibitor, TW-37, has been shown to effectively block antiapoptotic functions of Mcl-1 mediated through classical BH3-domain-dependent interactions.

Estrogenic actions can be mediated through classical and nonclassical ER signaling pathways, which are extensively reviewed by Barone and colleagues [ 17].

This interaction between antibodies and the endothelial cell causes stress to the microcirculation, mediated through classical complement activation, direct interaction of the antibody with the endothelium, or cell-dependent cytotoxicity via Fc receptors on neutrophils, NK cells, or macrophages [ 49].

For example, because the dissociated neuron cultures are low density by design, with limited cell-cell contact, the effects on neurite trajectory of neuroactive compounds like acetylcholine, adiphenine, baclofen and spiperone cannot be mediated through classical neurotransmission at functional synapses.

Therefore, in a subsequent experiment, GT1-7 cells were used to determine whether the differential effects of FGF8b on Fgfr1 and Fgfr3 expression are mediated through the classical membrane FGF receptors.

Additionally, the estrogenic activity of D3 in the uterus was mediated through both classical and nonclassical ERE-independent mechanisms.

Treatment of C4HD cells with the anti-progestin RU486 or silencing of PR expression using siRNAs overcame the MPA-induced miR-16 downregulation, indicating that this effect is mediated through the classical PR.

This response was inhibited by the antiestrogens raloxifene (data not shown) and tamoxifen, suggesting that the induction of Ar mRNA by E2 is mediated through the classical genomic estrogen receptor pathway.

Ee et al. [178] found that this stimulatory effect is mediated through the classical pathway that involves binding of E2/ER complexes on the estrogen response element in the BCRP promoter region.