Sentence examples for mediated through central from inspiring English sources

If the effect of Sirt1 on energy balance is mediated through central melanocortin signaling, blocking melanocortin receptors should reverse the anorexogenic outcome of Sirt1 inhibition.

The activity of methanol extract is most likely mediated through central and peripheral inhibitory mechanisms.

While KOP receptors are found throughout the peripheral nervous system and CNS (Minami et al., 1993), most of the analgesic efficacy of systemically administered KOP receptor agonists is mediated through central targets.

However, since the data were obtained from global GHS-R knockout mice, we could not determine with certainty whether the effect of GHS-R on thermogenesis is mediated through central SNS and/or peripheral brown adipocytes.

The aim of the present study was to investigate whether there was a contribution of NO to the high-pressure baroreceptor reflex regulation of RSNA and HR mediated through central AT2 receptors.

Our results are consistent with the hypothesis that the effect of exercise upon nutrient homeostasis and insulin sensitivity might be mediated through central effects of muscle-derived IL6 in promoting central leptin signalling.

Anorexia and nausea seem to be mediated through the central nervous system, with reflex input from nerve endings in the stomach and duodenum.

To further confirm that ghrelin's beneficial effects after gut I/R are mediated through the central nervous system, intracerebroventricular administration of ghrelin was performed at the beginning of reperfusion after 90-min gut ischemia.

The double-strand DNA breaks induced by cisplatin are mediated through a central DNA damage-signaling pathway controlled by the ataxia telangiectasia mutated (ATM) kinase as well as several other DNA damage-responsive kinases [7], [8].

To further confirm that ghrelin's beneficial effects after gut I/R are mediated through the central nervous system, ICV administration of ghrelin was performed at the beginning of reperfusion after 90-min gut ischemia.

Based on the above findings, we hypothesized that 1) EE treatments decrease the peripheral stress response as reflected in poor wound healing, and 2) that the effect of EE on the peripheral stress response is mediated through the central nervous system (CNS) and its effect on the HPA.