Sentence examples for mediated this genome from inspiring English sources

The massively amplified repetitive sequences may have mediated this genome shuffling.

We have established that, contrary to lytic KSHV infection, there is no enrichment of ARE-bearing transcripts among those that escape shutoff by SOX alone, suggesting that another viral protein (e.g., Kaposin B) or a cellular response to other aspects of infection (e.g., DNA damage response triggered by genome replication) mediates this effect.

In addition to genome wide rearrangements, IS elements appear to have mediated partial genome duplications in SOPE.

It seems unlikely that such a restricted analysis would have identified the only instances in which MITEs have mediated local genome rearrangements, and with the large number of deleted instances in the genome, it seems likely that MITE repeat sequences have played a large role in genome evolution of epichloae.

Cells have evolved with conserved recombination mediated genome editing pathways as a mean for repairing DSBs and restarting replication forks, thus allowing genome duplication to continue [8].

We used clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9)–mediated genome editing to correct the dystrophin gene (Dmd) mutation in the germ line of mdx mice, a model for DMD, and then monitored muscle structure and function.

Most commonly recognized effect is to facilitate chromosomal instability [4], probably mediated by hypomethylated genome associated replication independent DNA double strand break error prone repair [5], [6].

In addition, delivery of additional TALEN into the organism may increase the possibility of off-target cleavage, which is the major concern of hybrid nucleases mediated genome editing.

Patterns of insertion also support species designations, affirming CanSINEs as systematic markers and confirming complex evolutionary processes including incomplete lineage sorting following rapid species divergence, hybridization and SINE mediated genome rearrangement.

To address this question, we employed CAS9- (clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated systems 9) (Jinek et al., 2012) mediated genome editing to derive human pluripotent stem cells (WIBR#3) that carry TERT promoter mutations at the endogenous TERT locus.

This suggests that LIMPs can indeed mediate mitochondrial genome rearrangements, but that the vast majority of the molecules in our culture conform to our genome map.