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NSCs transduced with one, two, or none of these molecules had no or limited effect when injected at the chronic stage of experimental autoimmune encephalomyelitis; cocktail-producing NSCs, in contrast, mediated the most effective recovery through inducing M2 macrophages/microglia, reducing astrogliosis, and promoting axonal integrity and endogenous oligodendrocyte/neuron differentiation.

A lack of tenascin-R (TN-R−/−) mediated the most extensive degeneration with a radius of about 1500  μm of the affected cross-sectional area.

In an experiment comparing long, short, and intermediate hinges of a CAR against ROR1, the short-hinge CAR T cells mediated the most efficient response in terms of T cell killing and cytokine release, followed by the intermediate-hinge cells and the long-hinge cells [ 125].

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The Tet repressor (TetR) mediates the most important mechanism of bacterial resistance against tetracycline (Tc) antibiotics.

In fact, it's mediating the most successful attempt so far to achieve peace between the Colombian government and Farc rebels, making its inclusion on the US list of states that sponsor terrorism look increasingly outdated.

Subsequently, the shRNA sequence mediating the most effective knockdown was cloned into a lentiviral vector backbone to generate viral particles.

In fact, it mediates the most of the communications (72%) between the majority of the lncRNAs (68%) and their counterpart mRNAs (60%) in the network.

The 3D map also indicated that the ATPase-containing portion of Swr1 mediates the most significant contact between SWR1 and the nucleosome core particle.

GM-CSF is notable because it promotes dendritic cell (DC) differentiation, and may thus mediate the most effective presentation of tumor antigens (see below).

These studies have provided us with a clear rank order for the utility of this important class of enzymes as tools for vertebrate genome engineering with Bxb1 integrase mediating the most efficient and accurate site-specific recombination in this heterologous environment.

Mostly based on previous information, we make the following predictions: The integration of an alien plant into a pollination network is mediated by the most generalist (native or alien) pollinators [1], [3], [7], [13] and Opuntia interacts most frequently with generalist insects (super-generalists sensu [1]).

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