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However, in the cases analyzed here, clearly the inverted repeat sequences could not have mediated the initial breakage events that initiated the formation of the primary dicentric GCRs.
This indicated that Cavs mediated the initial phase of the [Ca2+]i elevations in NG2 cells while CICR was responsible for the late phase.
Also recently, Du et al. demonstrated that cell surface vimentin serves as an attachment site that mediated the initial binding and subsequently increased the infectivity of EV71.
Moreover, LTRs of different endogenous retroviruses have mediated the initial CNV-forming event, and the allelic extent of CNV in macaques is similar to humans (Hollox et al. 2003; Hardwick et al. 2011) and chimpanzees (Hardwick et al. 2011), which range from three to six copies per diploid genome.
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For example, salivary proteins mediate the initial accumulation of microorganisms in the human oral cavity [54].
Selectins mediate the initial, low-affinity leukocyte-endothelial cell interaction that is manifested as leukocyte rolling.
The P. vivax merozoite surface protein-1 (PvMSP-1) is a 200 kDa antigen, thought to mediate the initial contact between the merozoite and the erythrocyte.
It is well documented that the selectins mediate the initial interaction (rolling) of leukocytes in an inflamed vessel by binding to carbohydrate-presenting counter-receptors displayed on leukocytes.
The CAMs play a crucial role in determining synapse specificity by mediating the initial target recognition between pre- and post-synaptic neurons during synapse formation (Sanes and Yamagata, 2009; Williams et al., 2010).
Specifically, the transmembrane heparan sulfate proteoglycan, syndecan-1, is found to mediate the initial interactions of the particles at the cell surface, their coupling with actin filaments across the cell membrane, and their subsequent internalization via macropinocytosis.
Our data indicates that CD46 might not be involved in mediating the initial bacterial adhesion.
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