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Incorporating ASCs also mediated the inflammatory response and promoted a more constructive macrophage phenotype.
So ubiquitin mediated the inflammatory pathway of NF- κB which would lead to renal injury in diabetic rats [ 32].
More importantly, Aβ deposition mediated the inflammatory response of glial cells via inducing the expression of COX-2 in glioblastoma cells.
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TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia.
Dong, Y. et al. HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration.
Inflammatory cytokines mediate the inflammatory response (IL-1, IL-2, IL-6, IL-8, TNFα) and play a crucial role in the pathogenesis of OHSS.
Pivotal role in atherogenesis is played by macrophages, which are early site for lipid accumulation and mediate the inflammatory and immune response in the intima.
PGE2 signals through four G-protein-coupled receptors, including the EP2 receptor that has been investigated for its role in mediating the inflammatory and phagocytic responses to Aβ [4].
This observation is associated with the prevalent localization of the complex multimeric assembly of CGRP-R in the vascular smooth muscle where they mediate the inflammatory neurogenic vasodilatation.
The study in our laboratory (Wei et al., 2015) has shown that mtDNA released from necrotic cells induced by cationic carriers can mediate the inflammatory responses via TLR9 signaling, which reveals a novel mechanism about the inflammatory toxicity of cationic carriers and provides a new vision of designing better and safer cationic carriers for drug delivery.
Together suggesting CD28, through either CD80 or CD86 is capable of mediating the inflammatory response and lethality of polymicrobial sepsis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com