These results indicate that cysteinyl leukotrienes such as LTC4 and LTD4 produced by EGF stimulation mediated the second EGF-induced wave of lamellipodia formation in A431 cells.
In this study, we found that 5-lipoxygenase (5-LOX) is activated in the process of EGF-induced cell migration, and that leukotriene C4 (LTC4) produced by 5-LOX mediated the second wave of Rac1 activation, as well as cell migration.
The authors tested the hypothesis that endothelial NOS (eNOS) mediates the first window and inducible NOS (iNOS) mediates the second window of APC.
Nitric oxide synthases (NOSs) mediate the first window of anesthetic-induced preconditioning (APC).
DddD, the only characterized two-domain type III CoA-transferase, dually functions as a CoA-transferase and a lyase mediating the first two steps of dimethyl sulfide release from dimethylsulfoniopropionate (Supplementary Fig. 26c 30.
Because 8H3 binds to E2s region of HEV which has been proposed to mediate the first contact with host cells to initiate viral infection (He et al., 2008; Li et al., 2009; Tang et al., 2011), our results may have broad implications in understanding the protection mechanism of HEV vaccines and drugs designed against the HEV virus.
Psy1 is a nuclear encoded gene that mediates the first step in the plastid-localized carotenoid biosynthetic pathway.
Innate immunity mediates the first immune response to evolutionary conserved foreign patterns upon their recognition by pattern recognition receptors.
Adhesins are known to facilitate host colonization by mediating the first and crucial interaction with host tissue [10].
By non specific mechanisms such as phagocytosis and extracellular killing via toxic agents they mediate the first line of defense against infection.
One signaling pathway that is defective in a large proportion of cancer cells (∼70 75%) is the interferon (IFN) pathway, which mediates the first line of cellular anti-viral response [3], [4], [5], [6], [7].
