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Further comparison between systemic RASSF1A KO mice and cardiac-specific RASSF1A CKO mice revealed a paracrine mechanism involving TNF-α secretion by cardiac fibroblasts that mediated the enhanced growth and fibrosis observed in RASSF1A KO hearts [137].
We previously indicated that the enhanced activation of Akt and JNK mediated the enhanced production of MIP-1α [11].
All these results suggested that the activated PKCδ mediated the enhanced ubiquitination of C/EBPα protein under NSC606985 treatment.
In contrast, as only samples of cells expressing Ub-Lys showed a ubiquitination pattern comparable with the wild-type Ub, the Lys-linked polyubiquitin chains mediated the enhanced ubiquitination of Beclin 1 induced by the depletion of VPS34.
The novel finding of our present study is that receptor EphA2 mediated the enhanced induction of functionally altered claudin-2 via down-regulation of tumor suppressor gene expression cdx-2 in NSCLC cells.
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In cultured cell lines, several amino acid-responsive genes such as ASNS (Asparagine synthetase) [6], [7], [8] and CHOP (C/EBP homologous protein) [9], [10], [11] have been reported to contain AAREs (Amino Acid Response Elements) that mediate the enhanced transcription and function as enhancer elements [10].
We herein report, for the first time, on a dual-targeting strategy for mediating the enhanced targeting activity of NPs to adipose endothelial cells in diet-induced obesity (DIO).
A bilateral pair of dopaminergic neurons in the fly brain mediates the enhanced locomotor activity induced by ethanol exposure, and promotes locomotion when directly activated.
However, the mod-1 serotonin receptor that has been shown to mediate the enhanced slowing response does not promote the one-hour dwelling starvation response (Fig. 4).
In these experiments we used the Kv2.1-C1a peptide which corresponds to the syntaxin binding domain shown to mediate the enhanced DCVs' release [21].
Figure 2 showed that only the expression of LukS-PV signal peptide can mediate the enhanced bacterial attachment to ECM proteins.
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