These results confirm further that the bioactive RGDS peptide displayed on the surface is mediating the adhesion and spreading of the cells.
To mediate the adhesion processes, polymeric coatings have been used to functionalize surfaces to introduce diverse physicochemical properties.
Together, the CAMs mediate the adhesion response to external stimuli, and inside-out signaling transduction.
In 2000, Cirulli et al. demonstrated that αvβ3 and αvβ5 integrins could mediate the adhesion and migration of putative endocrine precursors [12].
Finally, TNFSF4 expressed on endothelial cells was reported to mediate the adhesion of TNFRSF4-expressing T-cells to vascular endothelial cells and the subsequent migration to distant inflammatory sites [35], suggesting an involvement of TNFSF4 in lymphocyte recruitment as well.
Then it mediates the adhesion, absorption and eradication of pathogen [ 2].
Integrins mediate the adhesion and transmigration of stem and progenitor cells.
Interestingly, CD44 can mediate the adhesion of platelets to hyaluronan secreted by fibrosarcoma cells [ 161].
These molecules mediate the adhesion of leukocytes, mainly monocytes, to vascular endothelium, and migration into the vessel wall.
