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These phenomena suggest that electrically mediated junctional transmission is older than chemically mediated synaptic transmission, which would require that some epithelial cells secrete chemical substances.
…suggest that electrically mediated junctional transmission is older than chemically mediated synaptic transmission, which would require that some epithelial cells secrete chemical substances.
A number of antiepileptic medications that modulate GABA(A) mediated synaptic transmission are anxiolytic.
These data provide indirect support against a potent role of the highly conserved C-terminal domain in APL-1 mediated synaptic transmission.
Although we could reliably evoke AMPAR mediated synaptic transmission, which confirmed intact connectivity in our working stimulation conditions, no detectable synaptic current was found after blocking AMPAR mediated currents with GYKI.
Moreover, BDNF enhances NR2B mediated synaptic transmission via activation of TrkB [ 14].
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Nehme, R. et al. Combining NGN2 programming with developmental patterning generates human excitatory neurons with NMDAR-mediated synaptic transmission.
We show that neuroligin-3 R704C-mutant iN cells exhibit a large and selective decrease in AMPA-type glutamate receptor-mediated synaptic transmission without changes in NMDA-type glutamate receptor- or in GABAA receptor-mediated synaptic transmission.
Urethane did not alter excitatory glutamate-mediated or inhibitory (GABA(A)- or GABA(B -mediated) synaptic transmission.
Finally, our data show that constitutive phosphorylation of the PKCζ substrate, p47phox, at S316 is sufficient to induce weakening of AMPAR-mediated synaptic transmission, even in the absence of upstream activator signals.
Our data showed significantly reduced AMPAR-mediated currents in S316D-transfected neurons (untransfected: 132.4 ± 12.9 pA vs. S316D transfected: 94.1 ± 9.4 pA, p = 0.023, Fig. 4f), indicating that phosphorylation at this residue is sufficient to reduce AMPAR-mediated synaptic transmission.
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