Sentence examples for mediated strictly from inspiring English sources

Although verification of the siRNA target gene can be easily done by generating multiple siRNAs targeting other regions of the gene, this strategy becomes problematic if the phenotype caused by the siRNA is mediated strictly by an "off-target" effect.

The mitotic centrosomes are critically important to mediate the strictly balanced bipolar separation of chromosomes.

FS cell soma-targeting synapses initiate a strong, global inhibition, those on shafts inhibit more restricted dendritic zones, while synapses on spines may mediate a strictly local veto.

Thus, the repression was mediated by a strictly maternal (i.e., extrachromosomal) effect.

These findings suggest that first pregnancy effects on later life breast density and cancer risk are not strictly mediated by later life sex steroid hormone levels.

Egr-1 expression was strictly mediated via Gαi/Src/p42/44 MAPK pathway; no involvement of the Gαq/11/PLC/PKC or the PLD/PI3 kinase/Akt pathways was found.

LPA induced a rapid and transient synthesis of Egr-1 that is strictly mediated via Gαi/Src/p42/44 MAPK pathway with no involvement of the Gαq/11/PLC/PKC or the PLD/PI3 kinase/Akt pathways.

The unique multi-threshold pattern in IgM-BCR activation is not strictly mediated by the outside-in or inside-out activation of the integrin molecules as addition of neither ICAM-1 nor FAK inhibitor changed that patterned dependence on mechanical forces in IgM-BCR activation.

The proportion of patients whose reactions are strictly IgE mediated in nature is unknown.

In mature human ECs, miR221/222 exhibit strictly antiangiogenic properties mediated by many targets.

In general, flow-evoked vasodilation is a complex Ca2+-dependent (as well as possibly Ca2+-independent), NO- and EDHF-mediated and strictly endothelium-dependent process [47] [49], which in these respects is remarkably similar to shear-stress induced vasodilation.