Associated with the calcium-mediated stabilisation of E-cadherin, the major cytoplasmic-domain partners of E-cadherin were also relocated to different intracellular compartments.
The antagonistic effect of BP-1 on CK19 expression could be due to interruption of PlGF-Flt-1-mediated stabilisation of CK19 protein.
In glioblastoma cells, bortezomib-mediated stabilisation of tBid was shown to facilitate TRAIL-induced cell death by amplifying apoptosis through the mitochondrial pathway.
N-WASP depletion can partially rescue this phenotype, suggesting that N-WASP-mediated stabilisation of junctional actin needs to be repressed for the delamination process to complete (Kesavan et al, 2009; Kesavan et al, 2014).
Enzalutamide reverses DHT-mediated thermal stabilisation of AR in a concentration dependent manner, showing competitive antagonism of agonist target engagement.
This response is largely driven by an increase in auxin synthesis, via low R FR-mediated stabilisation and activation of PHYTOCHR FR-mediatedING FACTOR (PIF) transtabilisationtors7.
By comparing the activity of 12.1 and Arf37 expressed as free peptides (unconstrained) or presented by CI2 (constrained), we show that scaffold-mediated stabilisation significantly enhances the activity of small peptides.
Alternatively, through Wnt signalling-mediated stabilisation, β-catenin may act as a downstream transcriptional transactivator of several target genes (Barth et al, 1997).
Innate tumour suppression in response to oncogenic stress includes the well-characterised ARF-mediated activation and stabilisation of p53 (Zindy et al, 2003; Christophorou et al, 2006; Efeyan et al, 2006) and the cellular DNA damage response (DDR) that is activated following oncogene-induced replicative stress (Halazonetis et al, 2008).
Moreover our data suggest that this is mediated by mechanisms that include stabilisation of Mcl-1 and reduced accumulation of cermide in the cell membrane, the latter mediated by AMPK activation.
