Sentence examples for mediated specifically through from inspiring English sources
The question then arises if the carprofen effect is mediated specifically through COX-2 and if it is species specific.
In line with research showing a relation between language and JA, this indicates that while JA is significantly related to functional outcomes, this appears to be mediated specifically through a verbal cognitive pathway.
The BAS Fun-Seeking scale was prospectively associated with PAEs, and there was a significant indirect path from Fun-Seeking to alcohol use mediated specifically through activity enhancement PAEs.
In particular, there is evidence for a complex role of IL-6 in the pathogenesis of OA, mediated specifically through its effect on the production of tissue inhibitors of metalloproteinases-1 (MMP-1), which might influence the extent of cartilage damage, post-injury, through negative feedback (Lotz and Guerne. 1991).
It is mediated specifically through H4R signaling since gene silencing or treatment with selective antagonists restores normal cell cycle progression.
This suggests that the drug delivery by apotransferrin nanoparticles is mediated specifically through transferrin receptor mediated endocytosis.
This event is mediated specifically by repression of the transcriptional activity of BRE through recruitment of the corepressor N-CoR, in which Nur77 binds to the BRE promoter, regulating the transcription of this protein [ 61, 62].
However, the SOM230 inhibitory effect in CAFs was shown to be specifically mediated through sst1, as demonstrated through sst1 expression knock-down (RNA interference) studies.
A point mutation of skeletal NTnC (E41A) abolishes the Ca2+-induced conformational change (but not Ca2+ binding), which shows that opening is effected through a mechanistic cascade, specifically mediated through the N-terminal Ca2+-binding site (site I) (38).
In this setup, overexpression of the flag-p21 overrode the siRNA effect and restored p21 protein level as well as TGFβ-induced cell invasion through the GFR-Matrigel barrier, indicating this effect is specifically mediated through p21.
In this case, the auxin flow may be directed, according to the signal flow canalization hypothesis [ 71], through a lateral transport mediated by specifically localized AECs such as MdPIN4.
