Exact(41)
Together, these findings raise the intriguing possibility that the establishment of cohesion in response to DNA damage is mediated specifically by the centromere-specific cohesion pathway.
The question then arises if the carprofen effect is mediated specifically through COX-2 and if it is species specific.
In line with research showing a relation between language and JA, this indicates that while JA is significantly related to functional outcomes, this appears to be mediated specifically through a verbal cognitive pathway.
The BAS Fun-Seeking scale was prospectively associated with PAEs, and there was a significant indirect path from Fun-Seeking to alcohol use mediated specifically through activity enhancement PAEs.
In particular, there is evidence for a complex role of IL-6 in the pathogenesis of OA, mediated specifically through its effect on the production of tissue inhibitors of metalloproteinases-1 (MMP-1), which might influence the extent of cartilage damage, post-injury, through negative feedback (Lotz and Guerne. 1991).
It is mediated specifically through H4R signaling since gene silencing or treatment with selective antagonists restores normal cell cycle progression.
Similar(19)
For example, different opsins activate different G-proteins, which are mediated by specifically known amino acids in opsin, as demonstrated by altering those amino acids experimentally (Franke et al. 1990; Marin et al. 2000).
However, the conclusion that MBON-α1 neurons mediate specifically LTM ("…we found a similar selective impairment of LTM upon the blockade of MBON-α1") is perhaps not entirely correct.
When the full length Lif 3′UTR was compared to a similar-sized human genomic sequence without conserved, genic or repetitive sequences this reduction was 55%, excluding that Lif mRNA destabilization was mediated non-specifically by its long 3′UTR sequence.
This result suggests that other pathways, including IL-17A, may be critical for mediating arthritis, specifically in the absence of IL-17F.
Folate, which mediates hydrolysis specifically in human NAT1 and mouse NAT2, may bind to effectively unpeel the third domain of NAT from the active site.
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