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This partitioning of AmOA1 mediated sensitivity to octopamine fits with a recent hypothesis that proposes different signaling roles for the two different olfactory tracts in the honey bee antennal lobes [54], [73].
Interindividual variability in PGP activity is therefore a strong candidate in genetically mediated sensitivity to methadone-induced respiratory depression.
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D. Stimulus response-functions: mechanical pain Stimulus response-functionsck stimechanicalynamic mechanical allodynia (DMA) assessment of A-delta fiber-mediated sensitivity to sharpainimuli (pinprick), asensitivity-beta fiber-MPSiatod pinprickstimuliy to stroking light touch (CW, cotton wisp; QT, cotton-wool tip; BR, brush).
Our results suggest that the MAD2-mediated sensitivity to cisplatin may be regulated through modification of the MEK pathway.
This mechanism is similar to that previously described in respect to cell-mediated sensitivity to microbial antigens.
These results suggest that MAPK pathways may be important in MAD2-mediated sensitivity to certain anticancer drugs.
FBP1 physically interacted with p53, impairing its transcription activity and reducing p53-mediated sensitivity to cellular stress.
Studies carried out using Bcl-2 siRNA in an XTT assay revealed that Bcl-2 alone cannot account for the difference in RUNX2-mediated sensitivity to apoptosis.
We further explored whether ERK1/2 activation is involved in the MnSOD siRNA-mediated sensitivity to apoptosis in response to chemotherapeutic agents.
To further confirm the importance of MEK pathway in MAD2-mediated sensitivity to cisplatin, we next studied whether inhibition of MEK1/2 had any effect on chemosensitivity to cisplatin in TGCT cells with high levels of MAD2.
Moreover, the effect of miR- 506 on cisplatin and olaparib sensitivity was rescued by overexpressing RAD51 without its 3′-UTR, suggesting that miR- 506-mediated sensitivity to cisplatin and olaparib is the result of the suppression of RAD51 expression.
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