Meisinger, C. et al. Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.
Gitai, Z., Dye, N. A., Reisenauer, A., Wachi, M. & Shapiro, L. MreB actin-mediated segregation of a specific region of a bacterial chromosome.
Another possibility is that the depletion of CTCF in the 5'UTR could disrupt a CTCF-mediated topological segregation of the expanded GAA triplet-repeat, a known source of PEV [5], from the 5'UTR and TSS of the FXN gene.
One hypothesis would be that homolog recognition, which depends upon Spo11-dependent recombination (noncrossover or even crossover), is followed by a Zip1-mediated segregation mechanism that occurs independent of its function in crossing over.
The model accounts for the experimentally observed anomalous low-temperature segregation of Sb as a consequence of the competition between step-edge-mediated segregation, dominant at low temperatures, and terrace-mediated segregation, dominant at higher temperatures.
This protection depends on kin-recognition-mediated segregation because it is compromised when we disrupt strain segregation.
This apparent segregation of different Nef-mediated phenotypes suggests distinct mechanisms of Nef action in different populations of target cells, and may be relevant to human AIDS.
A CTB-mediated GM1 crosslinking also triggered the segregation of micrometer-sized GM1-domains at 37°C in large (>10 μm) plasma membrane-derived spheres from A431 epidermoid carcinoma cells [ 48].
This competitive mechanism will introduce a stochastic nature into cell fate decisions, in contrast to the deterministic manner of Notch-mediated fate decisions, which require additional signaling or other factors, such as asymmetric segregation of Numb (Zhong et al. 1996).
Thus, future experiments could address whether the heterogeneity in endocannabinoid-mediated plasticity at spinal nociceptor synapses (Kato et al., 2012) results from spatial segregation of MGL and CB1 receptors into terminals innervating different postsynaptic target cell populations.
