Interestingly, sustained expression of FLAG-MCL-1 mediated resistance to the proapoptotic effects of flavopiridol.
Mee et al. (2008) have shown that p53 is upstream of NF-κB-mediated pathways of doxorubicin resistance and p53 is required for NF-κB mediated resistance to doxorubicin in NSCLC.
Therefore, the inhibitors of AXL or GAS6 may overcome the AXL-mediated resistance of EGFR-TKIs.
Of the proteins tested, XL5-HSA was the most effective competitor of α2AP-mediated resistance of fibrin clots to lysis.
Collectively these findings support the functional importance for MCL-1 in FLT3-ITD-mediated resistance of leukemia cells.
Thereby, imatinib may contribute to CXCL12/CXCR4 signaling-mediated resistance of the few remaining LSCs in CML.
Our demonstration that BAG3 is essential in the HSF1-mediated resistance of RKO cells to electrophile-mediated cell death stress suggests BAG3 may be a feasible target to sensitize cancer cells to radiation, chemotherapy, and immune-mediated toxicities.
More importantly, upon 1,25(OH)2D3 treatment, reintroduction of MICA, MICB, and ULBP2 reverses the miR-302c- and miR-520c-mediated resistance of malignant cells to the cytotoxicity of NK cells.
Many previous data revealed that plasmid-mediated resistance of N. gonorrhoeae confer the very high MICs of penicillinand tetracycline [ 47- 49], while chromosomally mediated resistance such as the site mutations at G120 or A121 in gonococcal PorB1B contributes to the moderate higher MICs of the two antibiotics [ 33, 34].
The STAT3-mediated resistance to apoptosis of those cells was independent of Bcl-2 expression [ 49].
It was possible that M27-mediated resistance to upregulation of immunoproteasome expression would protect infected cells from lysis by CD8+ T cell responses primed with constitutively immunoproteasome-rich cells [30].
