Here, we examined the localization and function of the two isoforms of zebrafish Pcdh15a (CD1 and CD3) in pcdh15a-null mutants by assessing Pcdh15a transgene-mediated rescue of auditory/vestibular behavior and hair cell morphology and activity.
Miller-Jensen, K., Janes, K. A., Wong, Y.-L., Griffith, L. G. & Lauffenburger, D. A. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis.
Consistent with this, I-BRD9-dependent reduction of Nanog and Klf4 expression was blunted when ESCs were cultured in 2i conditions (Fig. 8b), similar to 2i-mediated rescue of pluripotency gene expression in JQ1-treated ESCs, as was previously shown39.
Chong, L. D., Park, E. K., Latimer, E., Friesel, R. & Daar, I. O. Fibroblast growth factor receptor-mediated rescue of x-ephrin B1-induced cell dissociation in Xenopus embryos.
We showed that NaBt increased the levels of CBP expression by a 2.5-fold in PC12-ND6 cells (Fig. 6a), consistent with TSA-mediated rescue of CBP-knockdown in precursor neurons2.
DN-DaPKC-mediated rescue of ept tumor phenotypes was optimal at 20°C.
The use of protease-mediated rescue of GFP allowed for a relatively straightforward characterization of the substrate processing efficiency.
To test a possible time-dependency of the idebenone-mediated rescue of ATP levels, HepG2 cells were incubated with 6 µM rotenone for 60 minutes (Figure 3B).
Although the molecular events underlying PrP-mediated rescue of Dpl neurotoxicity are not well understood, one model suggested for this interaction is the binding of PrP to Dpl.
