Sentence examples for mediated regression from inspiring English sources

Bcl-2 is anti-apoptotic in function, whereas bax is proapoptotic and it is the interaction between the two that determines the likelihood of a tumor to undergo cytotoxic drug mediated regression.

Here, we review recent reports showing that intratumoral treatment with cps activated immune-mediated regression of established solid tumors in mice.

Successful immune-mediated regression of solid tumors is difficult because of the small number of cytotoxic T lymphocytes (CTLs) that were traffic to the tumor site.

This observation correlated with the PDT-mediated regression of the tumour and decrease in tumour volume.

In a screen of genes regulated during CLA-mediated regression of atherosclerosis, we identified several gene clusters, one of which contained the gene PGC-1α at its hub.

RESULTS: In a transcriptomic screen of genes regulated during CLA-mediated regression of atherosclerosis, we identified several gene clusters, one of which contained the gene PGC-1α at its hub.

In contrast to the results of our study, BMI1-mediated regression of p16 INK4A has been reported to contribute to an increased incidence of metastasis in melanoma patients [ 35].

Using stringent filtering of our data set to identify genes with a significant 1.7-fold differential expression, we identified PGC-1α as a hub gene within a network which was induced during CLA-mediated regression (Supporting Information Fig S1A).

To complement expression of the FAK-KD mutant protein in the cancer cells and investigate whether a FAK inhibitor could induce immune-mediated regression of SCC tumors, we used the FAK/Pyk2 kinase inhibitor VS-4718 (Shapiro et al., 2014), which is currently in clinical development.

This implied that FAK-expressing tumors were also under negative pressure from the immune system and that cells from the CD4+ T cell compartment play a role in protecting FAK-WT tumors from immune-mediated regression (reason discussed later; Figure 3).

Our data established also that treatment of mice with engrafted CML tumors with acadesine, mediated tumor regression.