Alternatively, does one observe preferential enrichment of specific TF motifs among the sites that acquire age-associated DNAm changes, which would then point to the importance of specific TFs in mediating this age-associated deregulation of DNAm patterns, analogous to the TF-mediated redistribution of DNAm patterns one observes in response to stem cell differentiation and disease (87, 88).
Thus, it is unlikely that the Ndel1 siRNA-mediated redistribution of GluR1 is due to remodelling of these organelles [20].
We simulate tip cell-mediated redistribution of VEGF in tissues and compare the results with experimental data [19], [53].
PTx significantly blocked basal-, [S1P]ext- and S1PL siRNA-mediated redistribution of Rac1 (Fig. 11A) and IQGAP1 (Fig. 11B).
The data show that ICAM-2-mediated redistribution of actin fibers and inhibition of tumor cell motility depended on an intact intracellular domain.
Molecular connections between the ring and spindle apparatus (e.g., [14] [16]) could provide the basis for understanding microtubule-mediated redistribution of contractile elements into the nascent ring.
Co-incident with observed ICAM-2-mediated redistribution of actin fibers was an inhibition of tumor cell motility (Figs. 2C and D), as assessed with two types of in vitro assays: scratch (wound) assays and modified Boyden chamber invasion assays.
If ICAM-2/α-actinin binding were essential to the observed ICAM-2-mediated redistribution of actin fibers, expression of ICAM2ΔCD would have no effect on actin fiber distribution and, similar to SK-N-ASpIRESneo cells, actin fibers in SK-N-ASpIRES.ICAM2ΔCD cells would be in a transverse configuration.
We next assessed whether the NIPA1-mediated redistribution of BMPRII to lysosomes results in increased degradation of BMPRII.
The RA-mediated redistribution of silencing proteins from the telomeres to the nucleolus is thought to be an adaptive response, and the rDNA locus is considered to be a hypothetical AGE locus (Kennedy et al. 1997).
On the basis of data present in the literature to date, it has been speculated that RTN-mediated redistribution could lead to an increase in PDi activity.
