Sentence examples for mediated receptor internalization from inspiring English sources
The precise mechanism(s) by which trastuzumab exerts its anti-tumor effects is unknown, although it is probably multi-factorial, including antibody-dependent cell mediated cytotoxicity [ 13], downregulation of HER-2 signaling following antibody mediated receptor internalization [ 14], inhibition of cell proliferation and survival signals [ 15, 16], and interference with DNA repair [ 17].
Ad-HER2-ki vaccine-induced potent T cell and antibody responses in mice and the vaccine-induced polyclonal HER2-specific antiserum mediated receptor internalization and degradation much more effectively than trastuzumab.
Rspo1 has been shown to augment Wnt signaling by interacting with the low-density lipoprotein receptor related protein 5 or 6 (LRP5/6) coreceptor and inhibiting Dickkopf-1 (Dkk-1) mediated receptor internalization [ 9].
Notably, knocking down endogenous tropomyosin expression using siRNAs that target different regions if tropomyosin resulted in complete inhibition of betaAR endocytosis, showing that non-muscle tropomyosin is essential for agonist-mediated receptor internalization.
MDC inhibits clathrin-mediated receptor internalization by stabilizing clathrin cage assembly, preventing clathrin polymerization [57], [58].
By contrast, Barlic et al., [17] showed that agonist induced phosphorylation of the chemokine receptor CXCR1 leads to β-arrestin-2-mediated receptor internalization and the formation of β-arrestin-2-Hck complex, which migrates to secretory granules initiating the process of degranulation.
The effects on agonist-mediated receptor internalization were monitored by automated confocal microscopy and image analysis.
In contrast to its role in G-protein-mediated signalling, the role of the TM6 toggle switch on agonist-mediated receptor internalization has not been widely explored.
26 This decrease was also evident by 4 hours after treatment (Fig 5C, D), consistent with immunostaining data demonstrating significant antibody-mediated receptor internalization at this time point.
NCS-1 can directly interact with postsynaptic D2 receptors in a Ca2+-dependent manner and inhibit receptor desensitization by preventing its phosphorylation through G protein-coupled receptor kinase 2 (GRK2, also known as ADRBK1), and thus beta-arrestin-mediated receptor internalization (Kabbani et al., 2002).
Reduced levels of the tyrosine phosphatase STEP block beta amyloid-mediated GluA1/GluA2 receptor internalization.
