Sentence examples for mediated progression of from inspiring English sources

RREB1 is expressed in developing tissues and cancer where it acts downstream of Ras and MAPK signaling Twist1 is required for K-Ras mediated progression of lung tumors, supporting a role for RREB1 in this regulatory interaction [ 29, 30].

Recent studies have suggested that NF-κB is the main transcription factor for the inflammatory response mediated progression of diabetic nephropathy.

Additionally, bone metastasis lesions-derived TGF-β can serve a critical mediator of breast carcinoma-mediated progression of osteolytic bone lesions, and the effector of this response is PTHrP.

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor involved in angiogenesis-mediated progression of acute myeloid leukemia (AML).

Despite the established role of sPRDM16 in leukemia development, the molecular mechanisms underlying sPRDM16 SUMOylation-mediated progression of AML remain elusive.

Such a mechanism may underpin the immune-mediated progression of pre-ALL to overt leukaemia following delayed postnatal infection (Greaves, 2006).

In this study, we demonstrated the involvement of EGF-EGFR signaling in NSCLC cell migration and the requirement of RAC1 in EGFR-mediated progression of NSCLC.

This process is further enhanced by the local release of monocytes-colony stimulating factor (M-CSF), which causes monocytic proliferation; local activation of monocytes leads to both cytokine-mediated progression of atherosclerosis and oxidation of low-density lipoprotein (LDL) [ 7].

Such polymorphisms have been described for the IL-6 receptor in Kaposi's sarcoma, and are believed to play a role in IL-6-mediated progression of this type of cancer [ 32].

As expected, our results showed that high glucose increased Smad4 expression in a concentration dependent manner, indicating that Smad4 is positively involved in TGF- β-mediated progression of DN.

A dominant negative ILK was capable of blocking IGFBP2-mediated progression of PDGFB induced gliomas, indicating that ILK may be a key downstream mediator of IGFBP2 signaling (Kristen Holmes and Wei Zhang, manuscript in preparation).