Kinetic measurements in combination with HPLC-mediated product analyses and site-directed mutation constructs indicated that Cel5A was strongly impaired when fused at the N-terminus, while activity was reduced to a slighter extend as C-terminal fusion partner.
Low BGL activity in T. reesei results in cellobiose accumulation leading to reduced biomass conversion efficiency and cellobiose-mediated product inhibition of CBH I (Cel7A) [ 76].
This gene codes for a DGC of the type that is subject to I-site-mediated product feedback inhibition, since DgcX features an intact A-site (the enzymatically active centre with the GG(D/E EF motif) as well as an I-site (a secondary c-di-GMP-binding site characterized by an RxxD motif only 5 amino acids upstream of the A-site; Supplementary Fig S1).
GPx provides an effective mechanism against cytosolic injury because it eliminates H2O2 and lipid peroxides (products of ·OH mediated peroxidation products) by reduction utilizing GSH [ 5].
Thus, these results suggest that the effect of Ang II on the erythrocytic parasite cycle could be mediated by its carboxypeptidase-mediated metabolic product Ang-(1 7).
It has previously been reported as an in-vitro cytochrome P450-mediated transformed product of exemestane [22].
Members of the FANCM family of helicases have been reported to promote SDSA-mediated NCO product formation by disrupting RAD51 coated D-loops [32, 67 69].
The PCR was initiated by using the telomerase mediated elongation products (i.e. the telomeric DNA repeats) as template.
Here we show that Ang II, through its carboxypeptidase-mediated metabolic product, Ang-(1 7), decreases infection of new erythrocytes during development of the P. falciparum blood stage.
αβ (mediated effect) product-of-coefficient estimate.
Its effects on osteoclasts are mainly indirect and mediated by products secreted by the osteoblast.
