The possibility of failure in antibody-mediated priming of effective cellular immune responses by preexisting vaccine-induced dominant responses may account for lack of viral control in the NAb-immunized vaccinee possessing MHC-I haplotype 90-088-Ij.
These data suggested important roles for the TLR4/MyD88/NF-κB pathway and RAGE/MyD88/NF-κB pathway in HMGB1-mediated priming of neutrophils.
Furthermore, IL-10 is able to inhibit dendritic cell-mediated priming of CD8+ T cells abrogating the induction of an anti-tumor CTL response [ 18].
IL-12 is required during early dendritic cell-mediated priming of both Th1 and TFH cells, suggesting that TFH and Th1 cells are derived under common innate immune signals [ 86].
Because it was shown earlier that previous exposure to H3N2 virus did not affect H5-specific ASC responses and the H1 HA and H5 HA share some structural similarity [18] and common epitopes [19], the effect of the H1N1-mediated priming on the H5N1 ca vaccines was investigated.
The exclusive presence of 80 kDa SNARE complex in the capacitated cavitated membrane fraction supports the possibility of SNARE-mediated docking and priming of PM and OAM.
It is possible that the replication defects observed with minimum licensed chromatin are also in part due to a defect in replication fork restart, which requires Polα-mediated re-priming of leading-strand synthesis.
Mutation of the non-expressor of PR genes 1 (NPR1) gene, a central node in SA-mediated defense signaling, blocks the priming of SAR (Cao et al. 1997).
It's been proposed that cytokines (predominantly TNFα -mediated NF-κB acTNFα -mediateds "priming" of hepatocytes to enhance their sensitivity to direct mitogens (such activation the procausesf liver regeneration [ 25].
In a previous study we demonstrated that highly purified LTA from S. aureus directly activated polymorphonuclear neutrophil granulocytes (PMN) resulting in morphological changes, shedding of CD62L, degranulation, cytokine release, priming of fMLP-mediated oxidative burst and delay in the spontaneous apoptosis [ 2].
We therefore argue that NAE inhibition-mediated replication stress may contribute to increased apoptotic priming of the CLL cells.
