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Qiao, S. W. et al. Dependence of antibody-mediated presentation of antigen on FcRn.

Komaniwa, S. et al. Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage.

To induce robust B- and T-cell responses, DN-2 would need to infect dendritic cells (DCs) effectively as activation of DCs is a critical event to initiate migration from the site of vaccine inoculation to draining lymph nodes where MHC-mediated presentation of cytoplasmic-synthesized peptide antigens to T cells occurs26,27,28.

Surprisingly however, severe viral infections have never been reported in these patients, despite the defect in HLA class I-mediated presentation of viral antigens to cytotoxic T cells.

In addition to recognizing certain microbial lipids, NKT cells have been found to respond specifically to CD1d-mediated presentation of endogenous cellular lipids [2].

Thus, an important area for future investigation is to understand how the CD1d-mediated presentation of cellular lipids relates to the immunological targeting of these lipids during disease pathogenesis.

These data indicate efficient HLA-DR-mediated presentation of endocytosed antigens after maturation.

Similarly, our data with the K14-mOVA transgenic lymph node transplantation and OT-II T cell transfer system confirmed that the peripheral maintenance of the Treg pool required MHC-II-mediated presentation of endogenous antigens as well.

Invariant natural killer T cells (iNKT cells) are restricted by CD1d molecules and activated upon CD1d-mediated presentation of glycolipids to T cell receptors (TCRs) located on the surface of the cell.

Some dendritic cells can internalize antigens homologous to those of H. contortus [ 83], so the specific response to H. contortus may be induced by the dendritic cell-mediated presentation of parasite antigens to helper T lymphocytes.

Collectively, and consistent with the well-established helper function of NKT cells (Van Kaer, 2004), these results suggested that IgG2a but not IgM responses depended on NKT cell activation, including cognate interactions between NKT cells and autoantibody-secreting B cells, likely mediated through presentation of microbial glycosphingolipid antigens.

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