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To investigate if structural proteins of EBV are presented via the receptor-mediated presentation pathway recently described for EBV glycoproteins [22], mini-LCL were pulsed with viral particles and tested for recognition by virion-specific T cells.
Qiao, S. W. et al. Dependence of antibody-mediated presentation of antigen on FcRn.
Komaniwa, S. et al. Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage.
To induce robust B- and T-cell responses, DN-2 would need to infect dendritic cells (DCs) effectively as activation of DCs is a critical event to initiate migration from the site of vaccine inoculation to draining lymph nodes where MHC-mediated presentation of cytoplasmic-synthesized peptide antigens to T cells occurs26,27,28.
Surprisingly however, severe viral infections have never been reported in these patients, despite the defect in HLA class I-mediated presentation of viral antigens to cytotoxic T cells.
In addition to recognizing certain microbial lipids, NKT cells have been found to respond specifically to CD1d-mediated presentation of endogenous cellular lipids [2].
Thus, an important area for future investigation is to understand how the CD1d-mediated presentation of cellular lipids relates to the immunological targeting of these lipids during disease pathogenesis.
Dendritic cell-mediated presentation launches the Tfh cell program.
The requirements for autophagy-mediated presentation are unknown.
These data indicate efficient HLA-DR-mediated presentation of endocytosed antigens after maturation.
Several molecules associated with MHC-I-mediated presentation such as B2m, Fcerg1 and Cd1d1 were also upregulated in our study.
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