Sentence examples for mediated pathways in from inspiring English sources

Objectives To evaluate the role of IL-10 mediated pathways in post-traumatic immune suppression and to assess the reversibility of this phenomenon.

These data suggest that while PS2 appears to interact with TLR4 mediated pathways in microglia its expression is sensitive to inflammatory signaling by IFN-γ.

In the cytosol, the elevated p70S6K activation in βIRKO cells could potentially serine-phosphorylate IRS1 and further dampen insulin-stimulation of Akt in βIRKO cells [43] (Fig. 7), and potentiate IGF-I mediated pathways in the mutant cells.

Also, the Cx43-GFP transfected N2A cells showed dye uptake under oxidative stress in the presence of purinergic blocker (Fig. 5A, A D) thus confirming the exclusion of purinergic mediated pathways in the dye transfer.

Our present findings highlight the importance of systemic non COX-1 mediated pathways inon COX-1's general mediatedms of action.

IgG-opsonized RBCs are cleared quickly through FcγR-receptor mediated pathways in the liver and spleen (Armour et al, 2006).

These pathways warrant further investigation and should be considered, in addition to the canonical SMAD mediated pathway, in the development of new therapeutic strategies targeting TGF−β signaling in GBM.

We also provide mechanistic insights suggesting that the activation of the translation signal, especially p70S6K through the PI3K/Akt mediated pathway in this process.

We demonstrated the disorganization of E-cadherin-β-catenin complexes and the regulation of vimentin expression by β-catenin mediated pathway in IDCs, thereby supporting the notion that Wnt/β-catenin signaling is implicated in regulation of EMT [ 21].

While little is known about the cross-talk between TLR2 and integrin-FAK-mediated pathways in the RA synovium, previous studies have reported that TLR2 mediates macrophage cytoskeletal rearrangement, promoting macrophage spreading and polarisation, a process required during extravasation and migration [ 43].

However, studies have also implicated HIF-independent NF-kB-mediated pathways in the host response at sites of inflammation, where NF-kB is required for the maintenance of epithelial barrier integrity [8, 21].