However, although protein gradients are now emerging as general motives to organize cells, tools to study gradient-mediated organization of three-dimensional space are limited.
Accordingly, integrin-mediated organization of the actin cytoskeleton regulates ERK nuclear translocation and activity44,45.
These findings are consistent with a contribution of self-mediated organization of keratin IFs to structural support and cytoarchitecture in basal layer keratinocytes of the epidermis, and underscore the importance of context-dependent regulation for keratins in vivo.
Therefore, dimerization-mediated organization of receptors can be affected differently by ligand stimulation.
Adenovirus relies on PI3K-mediated organization of actin filament for active internalization.
The work of Strasser et al. [23] suggested that Arp2/3 complex-mediated organization of branched filaments and three-dimensional networks residing in the center of growth cones may be important for growth cone translocation and guidance because these actin networks also functionally interface with the microtubule cytoskeleton.
In neural progenitors, the cell cycle machinery is closely associated with and actively controls INM at least in part through Tpx2-mediated organization of microtubules.
It remains an open question as to how defective GPI synthesis causes epilepsy, although a number of mechanisms have been suggested, including impaired Cripto signaling leading to aberrant forebrain development (44), and disruption of contactin-mediated organization of axonal subdomains at the node of Ranvier (42).
Endosomes can either isolate pathways from one another or mediate crosstalk between them, and at least 49 distinct endosomal "scaffolds" (i.e., endosome-mediated organizations of distinct pathways) have been identified.
Pyrite-mediated formation of.
In the case of lipid-mediated signaling, organization and metabolism of specific lipid mediators is an important aspect of such control.
