Sentence examples for mediated or not from inspiring English sources

Therefore, to evaluate whether early Smad activation caused by Gremlin was mediated or not by TGF- β, cells were preincubated with a neutralizing antibody against active TGF- β.

108 According to some authors, TNF-α, a transmembrane protein, could also explain alterations in gene expression of molecules evolved in glucose uptake, mediated or not by insulin, after a high-fat diet intake.

This is realized by endocytosis (receptor-mediated or not) of antigens at the apical membrane and exocytosis at the basolateral membrane by M cells and other enterocytes (Neutra et al., 1996; Lawson et al., 2011; Reineke et al., 2013).

sIgE measurements, SPTs, and oral food challenges are usually performed to determine if the problem is IgE-mediated or not.

A better understanding of the physiology of counter-regulation including how hypoglycaemia is sensed – whether glucokinase-mediated or not – and how these responses may become altered in diabetes could allow prevention of problematic hypoglycaemia.

We examined the overlap between AITD and the other 11 immune-mediated diseases that provided susceptibility loci to the ImmunoChip in turn, by testing whether the pattern of AITD association across immune-mediated disease regions differed according to whether those regions had previously been associated with each specific immune-mediated disease or not (Table  2; (16)).

From a mechanistic standpoint, AFRS and EFRS differ based on whether sinonasal inflammation is associated with an IgE-mediated process or not.

Azole resistance can be CYP51-mediated (categories i ii) or not CYP51-mediated (categories iii v).

Therefore, it appears that APC mutations uncouple AJ stability from Wnt-mediated regulation and, whether or not the Wnt pathway is activated, cadherin-bound β-catenin traveling from dissociated AJ may end up in the nucleus and presumably alters transcriptional regulation.

This hypersensitivity mechanism might either be allergic, i.e. related to the induction of IgE or IgG antibodies or of a cell-mediated response [ 30], or not allergic, i.e. related to a toxic or pharmacologic mechanism.

The key question of microglia in AD is whether the inflammation mediated via microglia is beneficial or not.