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Increased expression and nuclear translocation of SLUG are often correlated with the onset of EMT and our finding provides therefore a possible mechanistic explanation how EMT-associated events in fibrotic areas could be mediated on a transcriptional level.
Using a different transformation, the proportion mediated on a risk difference scale can also be calculated [ 8].
Statistical tests (non-parametric Wilcoxon Mann–Whitney) were performed in order to asses the difference between +1 and +2 (and +3, +4, …, +7) rise value distribution (dyad rise values mediated on a window of 90 bp).
Through mediated on a large conductance Ca2+-dependent K+ channels, cGMP-dependent protein kinase (PKG) phophorylates and rhoA, NO may attenuates vascular smooth muscle sensitivity to calcium ions [ 6].
The proportion mediated on a log odds scale can be calculated by taking the log of the mediated effect odds ratio divided by the log of the total effect odds ratio.
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