Together with the partial recovery of the flowering phenotype of AKIN10-overexpressing plants by the fus3-3 mutatitn, it has been suggested that the SnRK1-mediated metabolic signals are not solely mediated by FUS3 in regulating flowering time control [ 26].
These results suggest that the G1 arrest induced by knocking down eIF3 subunits is not mediated by Dap, or not solely by Dap, and that the underlying mechanism is distinct from that which mediates the COP9 signalosome and proteasome lid phenotypes.
The KKDC peptide, however, clustered efficiently both syndecan-1 and syndecan-4 (Fig. 2) and possibly additional syndecan family members, raising the possibility that enhanced cell adhesion and spreading is not solely mediated by syndecan-4.
However, calcitriol also inhibited proliferation in ER-negative cell lines, suggesting that growth inhibition induced by calcitriol is not solely mediated through the ER [ 12].
By contrast, depletion of cIAP-1 occurred in both sensitive and resistance cell lines after SM treatment, implying that the observed distinct SM response in HNSCC cell lines was not solely mediated by cIAP-1.
In both the cases no interaction or a very weak interaction was observed suggesting the interaction is not solely mediated by long C-terminal amino acid stretch but requires a complete OsMPK20-4 for efficient interaction.
These data suggests that activation of Stat1 per se is not sufficient to significantly sensitize U-266-1970 cells to Fas-induced apoptosis in the absence of IFN-γ stimulation, indicating that the effect of IFN-γ on Fas-induced apoptosis is not solely mediated by Stat1 activation.
Gene expression analyses in lipistase-treated LDLrKO and LDLrKO-PPARαKΟ mice provided evidence that PPARα contributes to the regulation by lipistase of both analysed pathways (Table 1 and Supplementary material online, Figure S4 ), but the action of lipistase is not solely mediated by PPARα.
It has been demonstrated that signaling pathways from contracting muscles to other organs are not solely mediated by the nervous system, since electrical stimulation of paralyzed muscles in spinal-cord-injured patients induces many of the same physiological changes as in neurological healthy individuals [ 66].
Capsaicin-induced cough may not solely be mediated through the nerves expressing TRPV1 receptors.
