Sentence examples for mediated neuron damage from inspiring English sources

Nevertheless, the precise mechanism of anti-INA mediated neuron damage remains unclear.

Interestingly, when Caspase-3 was blocked by a specific inhibitor, the neurite outgrowth was still impeded by anti-INA pAb, which suggested that apoptosis is the downstream effect of anti-INA mediated neuron damage (Figure 7).

Taken together, this study identified a novel anti-neurofilament aAb in NPSLE, and established a hitherto undescribed mechanism of aAb-mediated neuron damage that could have relevance to the pathophysiology of NPSLE.

Excitatory amino acid transporters (EAATs) are present in the plasma membranes of neurons and glial cells, and take up extracellular glutamate to regulate glutamatergic transmission and prevent glutamate-mediated neuronal damage [ 1– 3].

Understanding the role of ADAR2-mediated RNA editing in the neuronal damage pathway may prove essential in developing a specific therapy that minimizes side effects in uninjured neurons.

A KA-induced seizure causes neuronal damage in hippocampal pyramidal neurons and involves a caspase-3-mediated apoptotic pathway.

Moreover, an increase in AAP-mediated ROS levels could also contribute to neuronal damage.

Another will get a few hundred thousand dollars to examine ways such cells could repair neurons damaged by epilepsy and seizures.

This NO metabolites mediated DNA damage induces cellular apoptosis [ 40– 40].

We have shown that SIRT1 activators attenuate RGC loss during EAE optic neuritis [ 23- 25] however, neuronal damage in the MHV model of MS occurs by different mechanisms than in EAE, including direct viral infection of neurons and macrophage-mediated myelin stripping of axons [ 18].

CX3CR1 a key regulator of microglial function modulates inflammatory-mediated damage to neurons in the diabetic retina.