Sentence examples for mediated mostly by from inspiring English sources
The liver acquires specialized mechanisms of immune tolerance43, broadly by insufficient antigen presentation and a network of active immunosuppressive pathways mediated mostly by myeloid cells.
A common feature of neurotropic flaviviral infection is generation of inflammation in the CNS that is mediated mostly by glial activation and peripheral immune cell infiltration through a damaged and permeable blood brain barrier.
This process is mediated mostly by macrophages resident in the liver52,53, consolidating early observations regarding the central role of Kupffer cells in intercepting CTCs in an antibody-independent manner54.
The specificity of G protein receptor interaction is mediated mostly by the γ-subunit and the individual members of the γ-subunit multigene family would hence be expected to each have a particular expression profile.
The cell loses its surface anti-phagocytic "don't-eat-me" signals (mediated mostly by CD31 and CD47 glycoproteins) and exposes ligands designating the cell for phagocytosis (e.g. phosphatidylserine) [1], [2].
Therefore the effects previously assigned to T lymphocytes could indeed be mediated mostly by NK cells.
Physiological adaptation of cells is initially mediated by mostly transient and reversible covalent post-translational modifications (PTMs) at specific amino acid residues including ubiquitylation, sumoylation, and phosphorylation (see Appendix).
Generation of ROS by phagocytic cells, mostly mediated by Nox2, is activated by several stimuli through receptor-mediated protein kinase activation.
PCD can be initiated by an extrinsic pathway mostly mediated by caspase-8, or by an intrinsic pathway that involves caspase-9 activation (Kumar, 2007; Riedl & Salvesen, 2007).
At this contact, the adhesion energy is antagonized by cell tension, mostly mediated by the contractile actomyosin cell cortex underlying the contact [ 15,16,17,18 ].
Multivariable adjusted analyses suggested that enhanced placental cytokine expression (TNFα and IFNγ) was primarily influenced by oxidative stress, whereas leptin expression appeared to be mostly mediated by As, and IL-1β appeared to be influenced by both oxidative stress and As.
